Antigenic fragment definition11/27/2023 The antigen binding region also called paratope is a small part of variable region which recognizes and binds to an antigen. The tail of the “Y” is responsible for biological activity, such as C’ activity or binding to cells. The top one-fourth of it is the variable region of the heavy chain and the other three parts are the constant regions (CH1, CH2, CH3). Similarly, the heavy chain is divided into four parts. The top is the variable region of the light chain (VL) and the bottom is the constant region of light chain (VH). Each chain has two regions, the constant region (C) and the variable region (V). IgG is a heterotetrameric protein assembled from two identical heavy and light chains (H, L), assembled by disulfide bonds. Much has been learned about the antibody structure (Fig. They can protect us against infection and intoxication by mechanism of action for antibody functionality, such as antagonism, agonism, or cell killing via ADCC, ADCP, CDC, apoptosis PCD, or lysosomal-related PCD. Basically the function of antibodies is that control and stop pathogens and to assist in an immune response. They are peptide molecule secreted by b cells, mostly by differentiated B cells called plasma cells. Antibody is known as immunoglobulins which are generally Y-shaped. What is antibody (conventional antibody)?īefore we begin to introduce recombinant antibody, we should learn about antibody.
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